Parents need to know that the movie features explosions, fights, and vehicle chases. Characters drink, smoke, fight, and kill one another. Several scenes show clones in various unfinished states (incubating in sacks and on tables); others show organs harvested (surgery) and a baby harvested (the mother is killed after giving birth). While the protagonists' social naiveté and first grade reading skills make them seem childish, they are definitely adult in their sexual interests and fighting abilities. Characters and background images make frequent references to commercial products (including MSN, Puma, XBox, Aquafina, Cadillac, Ben & Jerry's).

Families can talk about the film's important ethical and philosophical questions concerning clones and organ harvesting: When do clones become individuals? Who can afford to purchase clones or organs, and how does this create a hierarchy of health, longevity, and cultural power? Does the fact that technology exists justify or compel its use? Families might also talk about how the film reduces resolutions for such dilemmas by broadly outlining villains and heroes, stereotypical relationships, and high-powered, plainly expensive action sequences.