NURSE BETTY centers on Betty (Renee Zellweger), a sweet, trusting woman married to a boorish used car salesman (Aaron Eckhardt). She does not know that her husband has stolen some heroin and hid it in one of his cars. When he’s killed by a hitman, Betty goes into what psychiatrists call a fugue state. She has no memory of seeing the crime. Instead, she thinks she has left her husband to find her former fiancé, a soap opera doctor. She sets off to find him, unaware she’s driving the car where her husband stashed the heroin. The two hitmen, Charlie (Morgan Freeman) and Wesley (Chris Rock), follow her. In L.A., she gets a job in a hospital, and meets the actor who plays her dream man. Charlie, too, is chasing a dream, wanting to finish this one last job so he can retire but growing more and more drawn to the woman he is supposed to kill.