Each week on FOXWORTHY'S BIG NIGHT OUT, comedian Jeff Foxworthy opens the show with a monologue, then segues into comedic sketches in which he's joined by castmates Brooke Dillman, Peter Oldring, Shane Caldwell, and others. Also on hand is the week's special guest (country stars like Kenny Rogers, Trace Adkins, and Hank Williams, Jr. have appeared in the past), who takes part in each skit before entertaining the audience with a live musical performance. For example, in a skit called "Celebrity Deer Hunter," Foxworthy discussed hunting with guest star Sara Evans, who later performed songs from her latest album. The show also features redneck words of the day (in one episode, "Sioux Falls" was highlighted, and Foxworthy defined it by explaining that "after she drinks, Sue falls") and offers audience members the chance to take the stage and interact with Foxworthy.