Unusual things happen in high school freshman Meg Murry's family. Her parents are famous scientists, and her six-year-old brother, Charles Wallace, is a genius. But Charles Wallace has been mysteriously ill, and when he tells Meg there are dragons in the garden, she worries that he is fantasizing.
Then she sees the fantastic creature, actually a "singular cherubim." It has been sent by a wise, humanlike Teacher to help Meg in a quest to heal Charles Wallace. Also accompanying her will be her friend, Calvin O'Keefe, and her archenemy, Mr. Jenkins, the dour principal of Charles Wallace's school.
The travelers journey from a faraway galaxy to inside Charles Wallace's body, where a cosmic battle is taking place. By kything--communicating without words--and learning the importance of Naming (loving) her enemies, Meg saves her brother with the help of both Calvin and the surprisingly lovable Mr. Jenkins.