After a night he can’t recall, Gulf War veteran Jack (Adrien Brody) is on trial for killing a policeman. He’s found not guilty by reason of insanity and sentenced to a mental hospital. Drugged and subjected to a horrifying test treatment, Jack begins to grope toward a memory of what really happened the night the policeman was killed. Diagnosed with "possibly acute retrograde psycho-suppression," Jack begins to hallucinate (however, the exact nature of his “visions” aren’t clear). Soulless Dr. Becker (Kris Kristofferson) is performing the tests on Jack, even though past efforts had disastrous results and his junior colleague Dr. Lorenson (Jennifer Jason Leigh) urges him to stop. Jack comes to want more of the treatment because it is his escape, whether real or imagined. And a waitress named Jackie, who appears in Jack’s visions, seems to be the key to solve a mystery more pressing than the murder of the policeman.