Parents need to know that this mature motion-capture animated film features dark, typically film-noirish themes: identity theft, DNA manipulation, murder, kidnapping, betrayal, and depression. There's lots of violence, rendered in harshly black-and-white, high-contrast animation (guns, knives, car chases/collisions, an explicitly and upsettingly dead dog). The first violent scene involves a young kidnap victim, who endures shooting all around him before being saved. The plot involves genetic research on humans, including photos of sad-looking subjects. A sexual encounter is implied by kissing; it's followed by a scene in which the couple smoke cigarettes. A gangster appears in a pool with naked women (breasts are visible). Characters smoke cigarettes, drink liquor, and use foul language.

Families can talk about the relationship between the two sisters: What does Brislane's dedication to saving Ilona have to do with their shared trauma as children? How does Karas' own youthful trauma contribute to his devotion to saving victims (especially kidnap victims)? What's so appealing about the idea of immortality via genetic engineering? Do you think it's a good idea? What are the risks? Why are ethical boundaries important when dealing with issues like this? Families can also talk about the movie's technique. Does motion-capture animation convey more or less emotion than other types of animation? How does the animation play into the film's noir nature?