In this not-exactly-long-awaited sequel to 2001's
Cats & Dogs, the nefarious cat Kitty Galore (voiced by
Bette Midler) masterminds a plan to make the entire canine population of the world go mad so that she and her feline followers can enslave humans. It's an ambitious scheme, especially since an elite, top-secret organization of dogs, DOGS -- led by distinguished beagle Lou (
Neil Patrick Harris) -- is out to stop her. Australian Shepherd Butch (
Nick Nolte), a veteran investigator, is tapped to break in rookie partner Diggs (
James Marsden), who's recruited after being let go from the San Francisco Police Department's K-9 unit. When the DOGS agents realize that catching Kitty requires some insider knowledge, they team up with their mortal enemies -- Catherine (
Christina Applegate) and other agents in the MEOWS squad -- to bring down the crazy cat.