Well there are no sexual references unless you are dumb or something, & they do swear like 5 times but there is pretty much swearing in a lot of songs nowadays. Also the song is called 12:51 not :51. Plus the alcohol reference really that isn't that big of a deal compared to what people listen to now.
There is some minor swearing, but nothing that you wouldn't hear walking through any American city. The Strokes present a strong, honest album here, and it is a definite follow-up to their last album, "Is This It". "Room on Fire" represents what may be the best period for this band.
Also: CSM is quite crazy for rating this 16+. It's an absolutely appropriate album.