WILL & GRACE -- one of the longest-running shows on network television featuring a homosexual lead character -- is a humorous take on the life of a gay New York City man and his straight female roommate, following them through their relationship successes and, more often, failures. The lead characters and show's namesakes, Will (Eric McCormack) and Grace (Debra Messing), have been friends since college, when they dated briefly before Will came out of the closet. Ever since, they've been best friends, eventually becoming roommates as well. The rest of the gang is rounded out by Will's best friend Jack (Sean Hayes), an aspiring entertainer who is also gay, and Grace's pill-popping, wisecracking assistant/close friend Karen (Megan Mullally), a Manhattan socialite who has a prescription drug habit and spends most of each episode ragging on her friends in a seemingly unfriendly manner. In almost every episode, though, she has a chance to redeem herself by doing a good deed for one of her friends.