Marmaduke (
Owen Wilson) lives happily in Kansas with the Winslows: marketing director Phil (
Lee Pace), stay-at-home mom Debbie (
Judy Greer), their teen, tween, and tot, plus their affable cat Carlos (
George Lopez). When Phil accepts a lucrative job working for an organic dog-food company, the Winslows and their pets move to Orange County, California, where the center of canine activity (and the informal office of Phil's new boss, played by William H. Macy), is the Laguna Beach Dog Park. Marmaduke immediately falls in with a clique of sweet mixed-breed outcasts -- tomboy Mazie (
Emma Stone), brainy Raisin (Steve Coogan), and neurotic Giuseppe (
Christopher Mintz-Plasse). But like high school, the "rulers" of the park are the alpha male Bosco (
Kiefer Sutherland), his beautiful girlfriend Jezebel (Stacy Ferguson), and their "pedigree crew." To win over Jezebel, Marmaduke makes a play for top dog, but alienates his true friends.