August has never been to school, because of surgeries to help him breathe, so when his mom sends him to Beecher prep, he panics. August’s face is deformed so he’s worried about seeing other kids . One, named Julian, is a bully. Another is Jack Will, who will be his best friend. August settles into school.
Julian becomes a big bully. He puts notes in August’s locker, but August and Jack send the notes back to him. Then he starts this game called “The Plague.” It’s if you touch August you will get the plague. Julian asks if August likes Emperor Palpatine from Star Wars (whose face is injured).
On Halloween, August decides to go as Bleeding Scream instead of Boba Fett. Then he hears Jack talking to Julian and Jack says that he's not really August's friend! August is feeling sick, so he goes home early. Meanwhile, Jack is so ashamed that he punches Julian and knocks out a baby tooth. He gets in huge trouble, but he and August make up. Summer is also August’s friend. She tells Jack why August hates him.
August’s sister thinks mean thoughts about him but she’s just mad because her friends have changed. But then she meets a boy her age who likes August, and she becomes nice again. But then their old dog die. August goes on a camping trip and gets beaten up by another school. Then, some of his friends help him. When August gets home, there is a package, and inside it is a puppy!
August considers himself a "scientific wonder." It matters because if you say his face is deformed it sounds really bad but if you say he's a scientific wonder it sounds amazing. The title of the book is "Wonder" because that's what everyone considers him by the end of the book.