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The good stuff
Overall, the movie has positive messages about family and career balance, the sacrifices you make for unconditional friendship, and the importance of teamwork among parents. That said, there are some iffier messages earlier in the film about the way you handle sexual relationships (Messer is a love-'em-and-leave-'em type) and what attributes make women attractive to men (Messer calls Holly boring and predictable).
Holly pursues professional success by working hard at her bakery and catering business. She accepts help from others but doesn't allow the men in her life to tell her what to do. She's also a caring and thoughtful caretaker who loves Sophie like a mother. Messer is ultimately a positive role model as well, but for the first half of the movie, he's an unrelenting, superficial jerk.
What to watch out for
References to the car accident that kills Sophie's parents. Holly accidentally lets go of Messer's motorcycle, and it crashes into a bus. A few baby pratfalls played for humor.
Many references to sex and sexual relationships. Messer is a "player" who's shown after a couple of one-night stands (the women are bare-shouldered in bed) and making out on many occasions, mostly in flashbacks. Two characters are shown kissing passionately, bumping into furniture, and tumbling into bed (sex is implied, with them in bed together afterward).
A few uses of "s--t" and "a--hole," plus "bi-ch," "d--k," "d--n," "laid," "hell," "oh my God," "idiot," "stupid," and more.
Product placements in several scenes include: SmartCar, the Atlanta Hawks, Volkswagen Routan, Cuisinart, BMW, The Wiggles, Wonder Pets, Adidas, Whole Foods, and Kitchen-Aid.
Drinking, drugs, & smoking:
In several scenes, the main characters drink beer or wine at dinners and parties. Holly drinks nearly an entire bottle of wine by herself. In one scene, a dad confiscates marijuana from three teenagers; in another sequence, Holly and Messer decide not to smoke the weed but instead bake it in brownies (and then eat them).
What other families should know
Too much sex
Great role models