Wesley (Nasim Pedrad) is a mess in DESPERADOS. No job, unpaid bills, no boyfriend, and she has just bungled an interview for a guidance counselor position in a Catholic school, as well as had a blind date that ended in disaster. Her best friends, Brooke (Anna Camp) and Kaylie (Sarah Burns), are sympathetic, but dealing with their own issues, too. It's Wesley, however, that's the constant center of conversation. Finally, she has a meet-cute, perfect date with Jared (Robbie Amell), the potential Mr. Right in her life. At least, momentarily. After one passionate evening, Wesley's phone doesn't ring for days. Wesley is certain she's has been "ghosted." Devastated and drunk, Wesley and her friends send Jared a mean-spirited, vengeful email. Unfortunately, just as they hit "send," Jared calls. He's been in an accident, comatose for the last five days in a hospital in Cabo San Lucas, Mexico. Wesley is horrified to learn that she has messed things up yet again. Not all is lost, however. Wesley has a plan. If she can make it to Mexico in time to intercept the email before Jared is released from the hospital, she may save herself. And so, with Brooke and Kaylie as support, Wesley takes off on a dizzying, chaos-filled trip to the posh resort where Jared's laptop is locked up in his "casita." Romcom mayhem ensues.