Parents need to know that the Italian film Out of My League has some quirky characters and scenarios as well as sexual situations, language, and a potentially sad central storyline. The main character is dying, and we see her at doctor's appointments, in the hospital, and stuck taking her many medications. But she is brave and maintains a plucky attitude. She also has the wholehearted support of her two best friends, a gay man and a lesbian woman who form her surrogate family since her parents died when she was three (and who are discussing forming a family of their own). We see couples having sex (man naked from behind and thrusting, part of the woman naked from the side, a woman in lingerie, a man shirtless, a woman in a bra) and kissing. There's discussion of menstruation, ovulation, insemination, and "S&M." Young adults drink at a bar. Language in the English subtitles includes "f--k," "f--king," "s--tty," "damn," "a--hole," "d--k," "bitch," "head-butt," "moron," "coward," "God," "jerk," and "balls."