Probably one of the funniest shows I've come across in a long time, lots of swearing, lots of sex (scenes of and conversations about), constant consumerism (it's set in Hollywood...), and lots of alcohol/pot consumption. Minimal violence, I can recall maybe a handful of fistfights between inebriated characters, no gore, no wife beating, child abusing, or rape.
None of the characters are amazing role models but none of them are bad all the way through. Very laid back show for the most part - the storyline does get more serious as it goes on with hard drugs, marital problems, and money issues all becoming themes, however none of these negative aspects are glamorized as one might expect.
Good show to watch if you're an adult who doesn't get easily offended, and if your kid is beyond the age where sex, drugs, and swearing are taboo then it's probably ok for them to watch too. The worst thing that will happen is they'll see naked people and learn some new swear word combinations.
What other families should know
Too much sex
Too much swearing
Too much consumerism
Too much drinking/drugs/smoking