HUFF's Dr. Craig "Huff" Huffstodt (Hank Azaria) is a great guy and a successful psychiatrist who was living a wonderful life until, in the series premiere, a 15-year-old patient killed himself in Huff's office. In the aftermath, Huff sees himself as a caregiver, but finds that he can't save everyone -- or maybe even anyone, including himself. Huff's best friend, Russell Tupper (Oliver Platt), provides counterpoint to Huff: Bed-hopping, drugs, and drinking are Russell's hobbies, and he is verbally abusive to his no-nonsense assistant. Meanwhile, Huff's mother, Izzy (Emmy-winning Blythe Danner), anesthetizes her emotional pain with alcohol; his mother-in-law, Madeline (Swoosie Kurtz), refuses painkillers in the late stages of cancer (because she "might miss something"); Huff's mentally ill brother, Teddy (Andy Comeau), is all angst and confusion trying to find stability; Huff's adolescent son, Byrd (Anton Yelchin), looks like the most stable member of the family but secretly breaks into other people's houses for mysterious reasons; and Huff's sexy, complicated wife, Beth (Paget Brewster), loves him but struggles with his issues as well as her own. A mysterious "homeless Hungarian" (Jack Laufer) appears to Huff in key moments -- part conscience, part guardian, part imaginary friend, this apparition may or may not be an indicator of Huff's own mental-health crisis.