Not for kids - no way, only for college kids
My husband find the show very funny, and while some of it would be very funny to teenagers, it's really not appropriate. The show last night showed a very elderly woman with just panties and pasties on pretending to be a 100 year old stripper. As part of the bit, 2 production assistants were twirling the pasties - no way that's appropriate for anything other than adults. Tosh also simulates various sexual acts, fully naked with just his privates blurred out a bit. So I'd say it's meant for college age - unlike say, the Daily Show, it's humor with no redeeming message. I find it funny, but no way my kids will see it (and the gross parts I watch with my hands over my eyes).
What other families should know
Too much violence
Too much sex
Too much swearing
Too much drinking/drugs/smoking